Updated 2026-09-06 · Prices in USD · Recall feed checked daily
🇺🇸 United States
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🇺🇸 United States · Routine care

Puppy Vaccine Series cost across United States

The full first-year set: 3 rounds of DA2PP plus rabies, usually bundled with exams.

$210–$380national typical range (USD)
San Franciscomost expensive city
San Antonioleast expensive city
Top 10

Where it costs most

Save money

Ways to pay less

  • Humane societies and low-cost clinics often run vaccine days at half price.
  • Ask about wellness plans that spread the cost monthly.
Full table

All 25 cities

CityTypical rangeIndex
San Francisco CA$300–$535
New York NY$285–$515
San Jose CA$275–$495
Los Angeles CA$265–$480
Boston MA$265–$480
Washington, DC DC$265–$480
San Diego CA$255–$460
Seattle WA$255–$460
Chicago IL$235–$420
Miami FL$235–$420
Portland OR$235–$420
Denver CO$230–$415
Philadelphia PA$225–$400
Austin TX$215–$390
Minneapolis MN$215–$390
Atlanta GA$210–$380
Las Vegas NV$210–$375
Dallas TX$205–$370
Houston TX$200–$365
Phoenix AZ$200–$365
Nashville TN$200–$365
Charlotte NC$200–$355
Detroit MI$190–$345
Columbus OH$190–$345
San Antonio TX$185–$335
FAQ

Questions

What is the average cost of puppy vaccine series in United States?

Nationally $210–$380 in 2026. San Francisco is the most expensive city we track; San Antonio the least.

Why do prices vary so much between cities?

Rent, staff wages, equipment and competition. Big-city specialty hospitals can charge double what a rural clinic does for the same procedure.

Does pet insurance cover puppy vaccine series?

Usually not, unless you add a wellness/routine-care rider.

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